Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2,3-Dioxygenase (IDO) Related Products (45):

By Effects:	Inhibitors (42) Antagonist (1) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-15760

Necrostatin-1	Inhibitor	99.89%
Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC₅₀ of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC₅₀=182 nM). Necrostatin-1 is also an IDO inhibitor.

HY-N0707

(S)-Indoximod	Inhibitor	99.47%
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (K_i: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease.

HY-112164

IACS-8968	Inhibitor	98.46%
IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC₅₀s of 6.43 for IDO and <5 for TDO, respectively.

HY-N0430A

Coptisine Sulfate	Inhibitor	99.37%
Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K_i value of 5.8 μM and an IC₅₀ value of 6.3 μM.

HY-153764

IDO-IN-18	Inhibitor
IDO-IN-18 (Compound 00815) is an IDO inhibitor. IDO-IN-18 can be used for research of immunosuppression associated infectious or cancer diseases.

HY-162962

IDO1/TDO-IN-7	Inhibitor
IDO1/TDO-IN-7 (Compound 43b), an isoquinoline derivative, is a potent dual IDO1/TDO inhibitor, with IC₅₀s of 0.31 μM and 0.08 μM, respectively. IDO1/TDO-IN-7 displays acceptable pharmacokinetic profiles and potent antitumor efficacy with low toxicity in B16-F10 tumor model.

HY-161996

IDO1-IN-25	Inhibitor
IDO1-IN-25 is a dual inhibitor of IDO1/TDO2, with IC₅₀ values of 0.17 μM and 3.2 μM, respectively. IDO1-IN-25 can effectively inhibit the production of NO in RAW264.7 cells stimulated by lipopolysaccharide (LPS). IDO1-IN-25 can exert anti-inflammatory effects in a mouse ear edema acute inflammation model induced by croton oil.

HY-168092

VS-15	Inhibitor
VS-15, a IDO1 inhibitor, selectively binds the heme-free form of IDO1. VS-15 is described as an iNOS inhibitor based on the reduction of NO production.

HY-139205

BMT-297376	Inhibitor	99.14%
BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.

HY-111540B

(S)-LY-3381916	Inhibitor	99.06%
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC₅₀ value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

HY-128355

IDO/TDO-IN-1	Inhibitor	99.22%
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC₅₀s of 9.7 and 47 nM, respectively .

HY-111540A

(Rac)-LY-3381916	Inhibitor	99.12%
(Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

HY-115122

IDO-IN-12	Inhibitor	99.22%
IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1.

HY-112164B

IACS-8968 S-enantiomer	Inhibitor	98.43%
IACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC₅₀s of 6.43 for IDO and <5 for TDO, respectively.

HY-N2463

Kushenol E	Inhibitor
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i of 9.5 µM, has anti-tumor activity.

HY-144651

IDO1-IN-18	Inhibitor	98.00%
IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has the potential for the research of cancer diseases.

HY-W113615

4-Phenyl-1H-1,2,3-triazole	Inhibitor	≥98.0%
4-Phenyl-1H-1,2,3-triazole is an IDO1 inhibitor (IC₅₀: 60 渭M). 4-Phenyl-1H-1,2,3-triazole can be used for cancer research.

HY-145332

IDO1-IN-11	Inhibitor
IDO1-IN-11 is an IDO1 inhibitor with an IC₅₀ value of 0.6 nM.

HY-145346

NLG802	Inhibitor	99.82%
NLG802 is a proagent of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.

HY-134583

IDO1-IN-7	Inhibitor
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer.

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